Sustained Release (SR) drug delivery system significantly improve therapeutic efficacy of a drug. Drug release retarding polymers are the key performer in such systems. Cimetidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn. Cimetidine has been linked to rare instances of clinically apparent acute liver injury. A commonly used agent for treatment of duodenal and gastric ulcer and gastroesophageal reflux disease. Mucoadhesive microcapsule were prepared by orifice ionic gelation method with polymers combinations such as carbopol and HPMC, carbopol and xanthan gum, carbopol and ethyl cellulose, carbopol and guar gum, against carbopol only, in the drug-polymer ratio of 1:3 w/w using cimetidine as model drug. The average particle size of the formulation F3 was found to be 739.2 �µm. The %yield of the prepared microcapsules was found to be 88.5 % for formulation F3, which is regarded as best formulation. Among all the prepared formulations formulation F3 was found to be the best formulation with a % drug release of 92.3%. The pattern of drug release was found to be zero-order kinetics.
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